Articles

Articles covering different aspects of downstream processing and manufacture of biotherapeutics

  • EvolveD - Infographic

    EvolveD - Infographic

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  • Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

    Re-use, Cleaning and sanitization of IsoClear™ Affinity Adsorbents

    A scale-down reuse study was performed on an automated chromatography workstation using a 2 mL IsoClear B™ column challenged with 50 CV of plasma per cycle.

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  • Quality First!

    Quality First!

    At Prometic Bioseparations we put product quality first and have committed to become the first chromatography adsorbent manufacturer to achieve full GMP compliance!

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  • Screening for chromatography adsorbent selection and optimisation for downstream processing of biopharmaceuticals

    Screening for chromatography adsorbent selection and optimisation for downstream processing of biopharmaceuticals

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  • Multi-Mode Ligand Library - Infographic

    Multi-Mode Ligand Library - Infographic

    Visualise our Multi-Mode Ligand Library through this infographic. A 18month custom programme patented since 1989.

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  • Endotoxins - Infographic

    Endotoxins - Infographic

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  • Prometic Bioseparations - Scaling up production

    Prometic Bioseparations - Scaling up production

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  • Ligand Discovery Projects

    Ligand Discovery Projects

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  • Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

    Capture and purification of Fab fragments from human polyclonal IgG papain digest using Fabsorbent™ F1P HF

    In response to demand we have developed an affinity adsorbent for the capture and purification of antibody fragments.

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  • Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?

    Is it really cost effective to develop a custom affinity ligand as a capture step in your downstream process?

    We offer an extensive range of off-the-shelf Bioseparation products for the recovery and purification of biologicals as well as purification services including bespoke custom designed chromatography.

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  • Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

    Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

    Removal of Isoagglutinins from IVIG and Plasma Using Affinity Chromatography

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  • Evolve™ Process Column: Customer Evaluation

    Evolve™ Process Column: Customer Evaluation

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  • The Evolve™ Process Column in NIBRT

    The Evolve™ Process Column in NIBRT

    User friendly and ergonomic; performance is comparable to more expensive columns and the single use aspect compares well to lengthy cleaning cycles.

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  • Endotoxin removal & β-D-Glucan Interference

    Endotoxin removal & β-D-Glucan Interference

    EtoxiClear™ has been shown to provide >3.4 log clearance of endotoxin from Fab fragments from an E. coli cell lysate, as well as from proteins such as IgG and HSA.

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  • EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

    EtoxiClear™: An novel affinity adsorbent for the efficient removal of endotoxin

    A number of methods have been adopted for the removal of endotoxin based on adsorption, in particular ion-exchange chromatography.

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  • Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

    Capture and purification of human serum albumin from human source plasma using Mimetic Blue® SA HL P6XL

    In this application note we describe how human serum albumin is captured and purified from human source plasma using Mimetic Blue® SA HL P6XL.

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  • Capture and purification of recombinant albumin-fusion proteins using AlbuPure®.

    Capture and purification of recombinant albumin-fusion proteins using AlbuPure®.

    AlbuPure® can be used to capture and purify recombinant albumin-fusion proteins from cell culture supernatants with high purity and recovery.

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  • Endotoxin Removal from Bench to Process Scale.

    Endotoxin Removal from Bench to Process Scale.

    Endotoxin or lipopolysaccharides (LPS) are highly toxic components of the cell wall of Gram-negative bacteria and are often present in significant amounts in bacterial cell expression systems.

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  • Immobilised Boronate Ligand Affinity Adsorbents for Glycoproteins

    Immobilised Boronate Ligand Affinity Adsorbents for Glycoproteins

    Review useful insights and data highlighting the importance of protein glycosylation in Biopharmaceuticals.

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  • Article: Disposable Column options

    Article: Disposable Column options

    Interest has been growing in the use of pre-packed disposable chromatography columns and in the use of disposable process fluid contact pathways.

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